Depression: Latest News & Research
Curated updates on depression research and treatment, updated monthly. Last updated: October 10, 2026.
This Month’s Highlights
Psilocybin passes a second large Phase 3 trial
In a trial of nearly 600 people with treatment-resistant depression, a psilocybin treatment given with psychological support produced rapid improvement that held through six months for many who responded. The company plans to complete its FDA application by the end of 2026; it is not yet approved. (Psychiatric Times, July 2026)
Treating inflammation instead of the brain
In a small pilot trial of 30 people with hard-to-treat depression and signs of inflammation, an anti-inflammatory drug led to remission in 54% of participants, compared with 31% on placebo. Larger studies are needed. (JAMA Psychiatry, May 2026)
Creatine as an add-on treatment
A review of five clinical trials found that adding creatine to standard treatment helped in some studies but not others. Researchers call the evidence promising but not yet conclusive, so talk with your doctor before trying supplements. (Brain Medicine, June 2026)
Exercise rivals standard treatments
A large review of research covering nearly 58,000 people found that exercise eased depression about as well as, or better than, medication or talk therapy. Aerobic activity and supervised or group programs showed the biggest benefits. (British Journal of Sports Medicine, February 2026)
This page shares general research news for education only. It is not medical advice and doesn’t replace care from a qualified professional. If you’re in crisis, call or text 988.